Wang G-H, Mitsui K, Kotliarova S, Yamashita A, Nagao Y, Tokuhiro S, Iwatsubo T, Kanazawa I, Nukina N: Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. Neuroreport 12:2435-2438, 1999

Lee J-A, Homma H, Tashiro K, Iwatsubo T, Imai K: D-Asprtate localization in the rat pituitary gland and retina. Brain Res 838:193-199, 1999

Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T: C terminus of presenilin is required for overproduction of amyloidogenic Aβ42 through stabilization and endoproteolysis of presenilin. J Neurosci 19:10627-10634, 1999

Nishiyama K, Ikezu T, Trapp BD, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Dekosky ST, Hsiao KK, Lisanti MP, Okamoto T: Caveolin-3 up-regulation activates γ-secretase mediated cleavage of the amyloid precursor protein (APP) in Alzheimer’s disease. J Neurosci 19: 6538-6548, 1999

Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T: Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid b peptides ending at Aβ40 and Aβ42. Neuroreport 10:2965-2969, 1999

Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H: Cerebrospinal fluid levels of amyloid β-peptide1-42, but not tau have positive correlation with brain glucose metabolism. Neurosci Lett 273:203-207, 1999

McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon, SE, Wang R, Hsiao K, Mann D, Dickson D, Duff K: Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis 6:231-244, 1999

Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C: A loss of function mutation of presenilin-2 interferes with amyloid β peptide production and Notch signaling. J Biol Chem 274:28669-28673, 1999

Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G: Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J Biol Chem 274: 13818-13823, 1999

Jakes R, Crowther RA, Lee VM-Y, Trojanowski JQ, Iwatsubo T, Goedert M: Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein. Neurosci Lett 269:13-16, 1999

Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A: Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer’s disease. Neurosci Lett 265: 61-63, 1999

Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, la Pompa JL, Furlonger K, Paige C, Hui Cc, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126:505-516, 1999