Yamamoto K, Tanei Z I, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno L E, Fukayama M, Bito H, Cirrito J R, Holtzman D M, Deisseroth K, Iwatsubo T: Chronic Optogenetic Activation Augments Abeta Pathology in a Mouse Model of Alzheimer Disease. Cell Rep 11:859-865, 2015

Hori Y, Hashimoto T, Nomoto H, Hyman B T, Iwatsubo T: Role of apolipoprotein E in beta-amyloidogenesis: isoform-specific effects on protofibril to fibril conversion of Abeta in vitro and brain Abeta deposition in vivo. J Biol Chem, 2015

Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K: Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer’s disease: a preliminary study. Radiol Phys Technol 8:64-72, 2015

Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T: Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of gamma-secretase. J Neurosci 35:2646-2656, 2015

Doody RS, Raman, R Sperling RA, Siemers E, Sethuraman G, Mohs R, Farlow MR, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS; Alzheimer’s Disease Cooperative Study: Peripheral and central effects of gamma-secretase inhibition by semagacestat in Alzheimer’s disease. Alzheimer’s Research & Therapy 7:36, 2015

Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T: Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity. Biochem Biophys Res Commun 457:194-199, 2015

Kukharsky M S, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman V L, Shelkovnikova T A: Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Mol Neurodegener 10:20, 2015

Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer’s disease brain. Hum Mol Genet 24:540-558, 2015