Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T: Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 amino-terminal elongation and fenofibrate. J Biol Chem 282:12388-12396, 2007

Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T: GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease. Biochemistry 46:1380-1388, 2007

Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kosaka K, Kato M, Iwatsubo T, Arai H: Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies. Neurosci Lett 415:219-224, 2007

Ishii A, Nonaka T, Taniguchi S, Saito T, Arai, T, Mann D, Iwatsubo T, Hisanaga S-i, Goedert M, Hasegawa M: Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human α-synuclein: Implication for α-synucleinopathies. FEBS letters 581:4711-4717, 2007

Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T: Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors. ACS Chemical Biology 2:408-418, 2007

Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M: Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein. J Neurosci Res 85:1819-1825, 2007

Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo’oka T: Analytical method for β-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of β-amyloid protein aggregation. Anal Chem 79:4887-4891, 2007

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T: Enhanced accumulation of phosphorylated α-synuclein and elevated Aβ42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer disease. J Neurosci 27:13092-13, 2007

Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi R, Hisanaga S-i, Iwatsubo T, Hasegawa M, Kato K: 920 MHz ultra-high field NMR studies of antibody binding and site-specific phosphorylation of α-synuclein. Biochem Biophys Res Comm 363:795-799, 2007

Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK, for the DLB/PDD working Group: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and Biomarkers. Neurology 68:812-819, 2007

Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T: Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Org Lett 9:2055-2058, 2007

Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Mizusawa H, Murayama S: Analysis of adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 66: 354-362, 2007

Haleem K, Lippa CF, Wong M, Abdelhak T, Smith TW, Kowa H, Iwatsubo T: Space-occupying plaques in PS-1 C410Y Alzheimer’s disease contain synaptic- terminal specific proteins. American Journal of Alzheimer’s Disease 22:137-144, 2007

Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T: The Tottori (D7N) and English (H6R) familial Alzheimer’s disease mutations accelerate Aβ fibril formation without increasing protofibril formation. J Biol Chem 282: 4916-4923, 2007