Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T: The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem 283: 34554-34562, 2008

Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren C-H, Kato T, Mitani S, Iwatsubo T: A large-scale RNA interference screen identifies endocytic pathway genes as modifiers of α-synuclein toxicity in transgenic Caenorhabditis elegans. Human Molecular Genetics 17:2997-3009, 2008

Sato C, Takagi S, Tomita T, Iwatsubo T: The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the γ-secretase. J Neurosci 28: 6264-6271, 2008

Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan C-F, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A: Homozygous and heterozygous patients for SNCA duplication in family with parkinsonism and dementia. Arch Neurol 65:514-519, 2008

Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K: Immunoreactivity of phage library-derived human single-chain antibodies to amyloid β conformers in vitro. J Biochem 143:475-486, 2008

Ichibangase T, Saimaru H, Takamura N, Kuwahara T, Koyama A, Iwatsubo T, Imai K: Proteomics of Caenorhabditis elegans overexpressing human α-synuclein analyzed by FD-LC-MS/MS method: actin and several ribosomal proteins were identified as negative markers at early Parkinson’s disease stages. Biomedical Chromatography 22:232-234, 2008

Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL: Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors. J Enzyme Inhib Med Chem 7:1, 2008

Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH: Evaluation of α-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 116:277-288, 2008

Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe, M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S: Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 67:945-953, 2008

Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG: Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson’s disease, but not tau-containing deposits in tauopathies. Neurodegener Dis 5: 222-224, 2008

Kumano K, Masuda S, Sata M, Saito T, Lee S-Y, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocytehomeostasis. Pigment Cell & Melanoma Research 21:70-78, 2008

Akanuma SI, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T: ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier. Neurochem Int 52:956-961, 2008

Obi, K Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H: Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 210:409-420, 2008

Cheung K-H, Shineman D, Muller M, Cardenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM-Y, Foskett K: Mechanism of Ca2+ disruption in Alzheimer’s disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58:871-883, 2008

Lo Bianco C, James Shorter C, Regulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P: Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson’s disease. J Clin Invest 118:3087-3097, 2008

Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S-i, Kobayashi K, Iwatsubo T, Yoshimoto M: Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice. Neurobiol Aging 29:574-585, 2008

Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhan J: Lysosomal enzyme cathepsin D protects against α-synuclein aggregation and toxicity. Molecular Brain 1:17, 2008

Takatori S. Ito G, Iwatsubo T: Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. Neurosci Lett 430:13-17, 2008