Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T: Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. J Neurosci 30: 15943-15950, 2010

Watanabe N, Takagi S, Tomita T, Iwatsubo T: Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate binding site of γ-secretase. J Biol Chem 285:19738-19746, 2010

Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H: Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator- activated receptor agonist library. Bioorg Med Chem Lett 20:5282-5285, 2010

Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K: Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer’s disease. J Neurosci Res 88:3588-3597, 2010

Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M: A non-competitive BACE1 inhibitor TAK-070 ameliorates Aβ pathology and behavioral deficits in a mouse model of Alzheimer’s disease. J Neurosci 30:11157-11166, 2010

Cheung KH, Mei L, Mak DOD, Hayashi I, Iwatsubo T, Kang DE, Foskett JK: Gain of function Alzheimer’s disease presenilin regulation of InsP3 receptor modal gating in patient cells and AD mouse neurons. Science Signaling 3:ra22, 2010

Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M: Seeded aggregation and toxicity of α-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem 285:34885-34898, 2010