Ochiai T, Sano T, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects of their deficiency on amyloid pathology in Alzheimer’s disease. Neurobiol Dis 159:105510, 2021

Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T, Iwatsubo T: Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease. J Prev Alzheimers Dis 4:483-494, 2021

Levine SZ, Goldberg Y, Yoshida K, Samara M, Cipriani A, Iwatsubo T, Leucht S, Furuwaka TA: Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: latent class analysis of individual-participant data from Five pivotal randomized clinical trials of donepezil. European Psychiatr 64: e16, 2021

Koh HS, Lee SJ, Lee HJ, Min J-W, Iwatsubo T, Teunissen CE, Cho H-J, Ryu J-H: Targeting microRNA-485-3p blocks Alzheimer’s disease progression. Int J Mol Sci 22:13136, 2021

Sato K, Niimi Y, Ihara R, Suzuki K, Toda T, Iwata A, Iwatsubo T: Efficacy and cost-effectiveness of multiple promotion methods to recruit participants to online screening registry for the facilitation of Alzheimer’s disease prevention trials. J Med Internet Res 23:e26284, 2021

Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, Wei R, Huo A, Saito T, Ando K, Murayama S, Araki W, Kametani F, Hasegawa M, Iwatsubo T, Tomomura M, Fukuda M, Hisanaga S-I: Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of beta-secretase BACE1. J Biochem 170:729–738, 2021

Samara MT, Levine SZ, Yoshida K, Goldberg Y, Clipriani A, Efthimiou O, Iwatsubo T, Leucht S, Furukawa TA: Linking the clinical dementia rating scale-sum of boxes, the clinician’s interview-based impression plus caregiver input and the clinical global impression scale: Evidence based on individual participant data from five randomized clinical trials of donepezil. J Alz Dis 82:1075-1084, 2021

Sato K, Mano T, Ihara R, Suzuki K, Toda T, Iwatsubo T, Iwata A: Cohort-specific optimization of models predicting preclinical Alzheimer’s disease, to enhance screening performance in the middle of preclinical Alzheimer’s disease clinical studies. J Prev Alzheimers Dis 8:503-512, 2021

Matsukawa K, Kukharsky, Park S-K, Park S, Iwatsubo T, Hashimoto T, Liebman S, Shelkovnikova T: Long non-coding RNA NEAT1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. RNA Biol 1-9, 2021

Levine SZ, Yoshida K, Goldberg Y, Samara M, Cipriani A, Efthimiou O, Iwatsubo T, Leucht S, Furukawa TA: Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale-Cognitive Subscale and the Severe Impairment Battery: Evidence from five randomized clinical trials. Evid Based Ment Health 24:56-61, 2021

Sato K, Ihara R, Suzuki K, Niimi Y, Toda T, Jimenez-Maggiora G, Langford O, Donohue MC, Raman R, Aisen PS, Sperling RA, Iwata A, Iwatsubo T: Predicting amyloid risk by machine learning algorithms based on the A4 screen data: application to the Japanese Trial-Ready Cohort study. Alzheimers Dementia: Translational Research & Clinical Interventions 7:e12135, 2021

Mano T, Sato K, Ikeuchi T, Toda T, Iwatsubo T, Iwata A: Peripheral blood BRCA1 methylation positively correlates with major Alzheimer’s disease risk factors. J Prev Alzheimers Dis 8:477-482, 2021

Sato K, Mano T, Niimi Y, Toda T, Iwata A, Iwatsubo T: Facial nerve palsy following the administration of mRNA COVID-19 vaccines. Int J Infect Dis 111:310-312, 2021

Sato K, Mano T, Niimi Y, Iwata A, Toda T, Iwatsubo T: The impact of COVID-19 pandemic on the provision of ambulatory care for patients with chronic neurological diseases in Japan: evaluation of an administrative claims database. BioScience Trends 15:219-230, 2021

Senda M, Ishii K, Ito K, Ikeuchi T, Matsuda H, Iwatsubo T, Iwata A, Ihara R, Suzuki K, Kasuga K, Ikari Y, Niimi Y, Arai H, Tamaoka A, Arahata Y, Itoh Y, Tachibana H, Ichimiya Y, Washizuka S, Odawara T, Ishii K, Ono K, Yokota T, Nakanishi A, Matsubara E, Mori H, Shimada H: A Japanese multicenter study on PET and other biomarkers for subjects with potential preclinical and prodromal Alzheimer’s disease. J Prev Alzheimers Dis 8:495-502, 2021