Pickering-Brown S, Baker M, Yen S-H, Liu W-K, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, Hutton M: Pick’s disease is associated with mutations in the tau gene. Ann Neurol 48:859-867, 2000

Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim S-H, Thinakaran G, Sisodia SS, Snyder SH: Amyloid precursor proteins inhibit heme oxygenase activity and augument neurotoxicity in Alzheimer’s disease. Neuron 28: 461-473, 2000

Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin : A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer’s disease but not with Aβ loading in brains. Neurosci Lett 293:29-32, 2000

Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi S, Morita T, Iwatsubo T, Takahashi H: Primary progressive aphasia with focal glial tauopathy. Neuropathol Appl Neurobiol 26:477-481, 2000

Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi K: α-synuclein inclusions in amygdala in the brains of patients with Parkinsonism-Dementia Complex of Guam. J Neuropathol Exp Neurol 59: 585-591, 2000

Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DMA, Hyman BT, Iwatsubo T: Age-related amyloid β deposition in transgenic mice overexpressing both presenilin 1 and amyloid β precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157: 331-339, 2000

Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Down’s syndrome. Alzheimer Report 3:77-82, 2000

Saura CA, Tomita T, Soriano S, Takahashi M, Leem J-Y, Honda T, Koo EH, Iwatsubo T, Thinakaran G: The non-conserved hydrophilic loop domain of presenilin is neither required for presenilin endoproteolysis nor enhanced Aβ42 production mediated by FAD-linked PS variants. J Biol Chem 275:17136-17142, 2000

Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of tau gene. Neurology 54:1787-1795, 2000

Yasuda M, Takamatsu J, D’Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Iwatsubo T, Goedert M, Schellenberg G, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47:422-429, 2000

Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T: Molecular cloning and characterization of a novel CLIC-related protein, parchorin, expressed in water-secreting cells. J Biol Chem 275:11164-11173, 2000

Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-calpain. Int J Mol Med 5:269-273, 2000

Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H: Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disese) with diffuse neurofibrillary and Lewy body pathology. Acta Neuropathol 99:331-336, 2000

Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle P, Haass C: Constitutive phosphorylation of the Parkinson’s disease associated α-synuclein. J Biol Chem 275:390-397, 2000

Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T: C terminus of presenilin is required for overproduction of amyloidogenic Aβ42 through stabilization and endoproteolysis of presenilin. J Neurosci 19:10627-10634, 1999

Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Itoh M, Iwatsubo T, Tomita T, Sasaki H: Cerebrospinal fluid levels of amyloid β-peptide1-42, but not tau have positive correlation with brain glucose metabolism. Neurosci Lett 273:203-207, 1999

Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T: Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid b peptides ending at Aβ40 and Aβ42. Neuroreport 10:2965-2969, 1999

Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C: A loss of function mutation of presenilin-2 interferes with amyloid β peptide production and Notch signaling. J Biol Chem 274:28669-28673, 1999

Wang G-H, Mitsui K, Kotliarova S, Yamashita A, Nagao Y, Tokuhiro S, Iwatsubo T, Kanazawa I, Nukina N: Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. Neuroreport 12:2435-2438, 1999

McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon, SE, Wang R, Hsiao K, Mann D, Dickson D, Duff K: Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol Dis 6:231-244, 1999

Lee J-A, Homma H, Tashiro K, Iwatsubo T, Imai K: D-Asprtate localization in the rat pituitary gland and retina. Brain Res 838:193-199, 1999

Jakes R, Crowther RA, Lee VM-Y, Trojanowski JQ, Iwatsubo T, Goedert M: Epitope mapping of LB509, a monoclonal antibody directed against human α-synuclein. Neurosci Lett 269:13-16, 1999

Nishiyama K, Ikezu T, Trapp BD, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Dekosky ST, Hsiao KK, Lisanti MP, Okamoto T: Caveolin-3 up-regulation activates γ-secretase mediated cleavage of the amyloid precursor protein (APP) in Alzheimer’s disease. J Neurosci 19: 6538-6548, 1999

Murayama O, Tomita T, Nihonmatsu N, Murayama M, Sun X, Honda T, Iwatsubo T, Takashima A: Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer’s disease. Neurosci Lett 265: 61-63, 1999

Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, Thinakaran G: Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J Biol Chem 274: 13818-13823, 1999

Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, la Pompa JL, Furlonger K, Paige C, Hui Cc, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126:505-516, 1999