Iseki E, Marui W, Kosaka K, Akiyama H, Ueda K, Iwatsubo T: Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease. Neurosci Lett 258:81-84, 1998

Hosomi A, Goto K, Kondo H, Iwatsubo T, Yokota T, Ogawa M, Arita M, Aoki J, Arai H, Inoue K: Localization of alpha-tocopherol transfer protein in rat brain. Neurosci Lett 256:159-162 1998

Naruse S, Thinakaran G, Luo J-J, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty, DD, Price, DL, Borchelt DR, Wong PC, Sisodia SS: Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 17:1213-1221, 1998

Hosoda R, Saido TC, Otvos LJr, Arai T, Mann DMA, Lee VM-Y, Trojanowski JQ, Iwatsubo T: Quantification of modified forms of amyloid β peptides in Alzheimer’s disease and Down’s syndrome brains. J Neuropathol Exp Neurol 57: 1089-1095, 1998

Lippa CF, Fujiwara H, Mann DMA, Giasson B, Baba M, Schmidt ML, Nee LE, O’Connell B, Pollen DA, St Geroge-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM-Y, Iwatsubo T, Trojanowski JQ: Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer’s disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol 153:1365-70, 1998

Sakai K, Homma H, Lee JA, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: Emergence of D-aspartic acid in the differentiating neurons of the rat central nervous system. Brain Res 808: 65-71, 1998

Long Z, Homma H, Lee JA, Fukushima T, Santa T, Iwatsubo T, Yamada R, Imai K: Biosynthesis of D-aspartate in mammalian cells. FEBS Lett 434:231-235, 1998

Tu P-H, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, Nakajo S, Iwatsubo T, Trojanowski JQ, Lee VM-Y: Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44: 415-422, 1998

Mann DMA, Pickering-Brown SM, Baba M, Iwatsubo T: Amyloid β protein (Aβ) deposition in dementia with Lewy bodies: predominance of Aβ42(43) and paucity of Aβ40 compared with sporadic Alzheimer’s disease. Neuropathol Applied Neurobiol 24: 187-194, 1998

Takigawa Y, Homma H, Lee J-A, Fukushima T, Santa T, Iwatsubo T, Imai K: D-aspartate uptake into cultured rat pinealocytes and the concomitant effect on L-aspartate levels and melatonin secretion. Biochem Biophys Res Comm 248: 641-647, 1998

Kanai M, Matsubara E, Isoe K, Urakami K, Nakashima K, Arai H, Sasaki H, Abe K, Iwatsubo T, Kosaka T, Watanabe M, Tomidokoro Y, Shizuka M, Mizushima K, Nakamura T, Igeta Y, Ikeda Y, Amari M, Kawarabayashi T, Ishiguro K, Harigaya Y, Wakabayashi K, Okamoto K, Hirai S, Shoji M: Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40 and Aβ1-42(43) in Alzheimer’s disease: A study in Japan. Ann Neurol 44: 17-26, 1998

Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T: Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid β peptides: Inability of truncated forms of PS2 with familial Alzheimer’s disease mutation to increase secretion of Aβ42. J Biol Chem 273: 21153-21160, 1998

Shinozaki K, Maruyama K, Saido TC, Kume H, Tomita T, Iwatsubo T, Obata K: The presenilin 2 loop domain interacts with the μ-calpain C-terminal region. Int J of Mol Med 1: 797-799, 1998

Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grunberg J, Ueyama Y, Haass C, Ihara Y: Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid β-protein (Aβ)42 in the brain. J Neurochem 71:313-322, 1998

Baba M, Nakajo S, Tu P-H, Tomita T, Nakaya K, Lee VM-Y, Trojanowski JQ, Iwatsubo T: Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. Am J Pathol 152: 879-884, 1998

Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T: The presenilin 1 mutation (M146V) linked to familial Alzheimer’s disease attenuates the neuronal differentiation of NTera 2 cells. Biochem Biophys Res Comm 244: 751-755, 1998

Sakai K, Homma H, Lee J-A, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: Localization of D-aspartic acid in elongate spermatids in rat testis. Arch Biochem Biophys 351: 96-105, 1998

Tomita T, Chang TY, Kodama T, Iwatsubo T: βAPP γ-secretase and SREBP site 2 protease are two different enzymes. Neuroreport 5: 911-913, 1998

Schmidt ML, Lee VM-Y, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ: Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of Aβ similar to those found in the amyloid plaques of Alzheimer’s disease and pathological aging. Acta Neuropathol 95:117-122, 1998

Sakurai Y, Matsumura K, Iwatsubo T, Momose T: Frontal pure agraphia for Kanji and Kana: dissociation between morphology and phonology. Neurology 49:946-952, 1997

Galvin JE, Lee VM-Y, Baba M, Mann DMA, Dickson DW, Yamaguchi H, Schmidt ML, Iwatsubo T, Trojanowski JQ: Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit. Ann Neurol 42:595-603, 1997

Cook DG, Forman M, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM-Y, Doms RW: Alzheimer Aβ (1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Med 3:1021-1023, 1997

Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T: Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport 8:2797-2801, 1997

Sakai K, Homma H, Lee J-A, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Imai K: D-aspartic acid localization during postnatal development of rat adrenal gland. Biochem Biophys Res Comm 235:433-436, 1997

Takamatsu J, Kimura T, Kondo A, Iwatsubo T: Subpial amyloid plaques in the cerebellum in a case of Alzheimer’s disease. Dement Geriatr Cogn Disord 8:157-162, 1997

Kosaka T, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, Imai K, Iwatsubo T: The βAPP717 Alzheimer mutation increases the percentage of plasma amyloid β protein ending at Aβ42(43). Neurology 48:741-745, 1997

Lee J-A, Homma H, Sakai K, Fukushima T, Santa T, Tashiro K, Iwatsubo T, Yoshikawa M, Imai K: Immunohistochemical localization of D-aspartate in the rat pineal gland. Biochem Biophys Res Comm 231:505-508, 1997

Mann DMA, Pickering-Brown SM, Byatti NN, Wright AE, Owen F, Iwatsubo T, Saido TC: An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid β protein deposition in Alzheimer’s disease. Neurosci Lett 222:57-60, 1997

Mann DMA, Iwatsubo T, Pickering-Brown SM, Owen F, Saido TC, Perry RH: Preferential deposition of amyloid β protein (Aβ) in the form of Aβ40 in Alzheimer’s disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neurosci Lett 221:81-84, 1997

Mann DMA, Iwatsubo T, Nochlin D, Sumi M, Levy-Lahad E, Bird TD: Amyloid (Aβ) deposition in chromosome 1-linked Alzheimer’s disease. –The Volga German families. Ann Neurol 41:52-57, 1997

Tomita T, Maruyama K*, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Gruenberg J, Haass C, Iwatsubo T*, Obata K: The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 94:2025-2030, 1997 (*corresponding author)