Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T: The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem 277: 50198-50205, 2002

Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann DMA, Iwatsubo T: Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002

Leem JY, Saura CA, Pietrzik C, Kim S-H, Veselits ML, Christianson J, Wanamaker C, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo E-H, Thinakaran G: A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 11:64-82, 2002

Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J Clin Invest 110: 1429-1439, 2002

Matsushita S, Arai H Okamura N, Ohmori T, Takasugi, Matsui T, Murayama M, Iwatsubo T, Higuchi S: Clinical and biomarker investigation of a patient with a novel PS-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer’s disease. Biological Psychiatry 52:907-910, 2002

Hayes A, Thakera U, Iwatsubo T, Pickering-Brown SM, Mann DMA: Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimer’s disease. Neurosci lett 331: 171-174, 2002

Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak T W, Penninger J M, Nishina H, Katada T: SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis. Dev Biol 250: 332-347, 2002

Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Haass C, Takeda M: Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1. EMBO J 21:5408-5416, 2002

Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neurosci Lett 330:84-88, 2002

Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DMA: The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer’s disease. Neurosci Lett 328:314-318, 2002

Araria-Goumidi L, Lambert JC, Mann DMA, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin MC: Association study of three polymorphisms of TGF-β1 gene with Alzheimer’s disease. J Neurol Neurosurg Psychiatr 73:62-64, 2002

Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294:429-440, 2002

Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C: Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Report 3: 583-588, 2002

Green EK, Harris JM, Lemmon H, Lambert JC, Chartier-Harlin MC, St Clair D, Mann DMA, Iwatsubo T, Lendon CL. Are interleukin-1 gene polymorphisms risk factors or disease modifiers in Alzheimer’s disease. Neurology 58:1566-1568, 2002

Tomita T, Katayama R, Takikawa R, Iwatsubo T: Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS lett 520:117-121, 2002

Green EK, Thaker U, McDonagh AM, Iwatsubo T, Lambert JC, Chartier-Harlin MC, Harris JM, Pickering-Brown SM, Lendon CL, Mann DMA: A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer’s disease, nor does it influence the extent of tau pathology in the brain. Neurosci Lett 324:113-116, 2002

Miake H, Mizusawa H, Iwatsubo T*, Hasegawa M*: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002 (*corresponding author)

Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 277: 14965-14975, 2002

Lambert J-C, Thaker U, Green EK, Harris JM, McDonagh AM, Iwatsubo T, Chartier-Harlin MC, Pickering-Brown SM, Lendon CL, Mann DMA: The -48 C/T polymorphism within the promotor region of the presenilin-1 gene does not influence the extent of tau pathology within the brain in sporadic Alzheimer’s disease. Alzheimer’s Reports 5:13-16, 2002

Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51:525-530, 2002

Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T: CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J 21:1524-1534, 2002

Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: α-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biol 4:160-164, 2002

Ikegaya Y, Kim J-A, Baba M, Iwatsubo T, Nishiyama N, Matsuki N: Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: Implication for a cellular defense against excitotoxicity. J Cell Sci 114:4083-4093, 2001

Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C: Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159:2215-2225, 2001

Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T: The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation and γ-secretase activities of presenilins. J Biol Chem 276:33273-33281, 2001

Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309:89-92, 2001

Mann DMA, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T: Cases of Alzheimer’s disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic β amyloid pathology known as “cotton wool” plaques. Neuropathol Applied Neurobiol 27:189-196, 2001

Lambert J-C, Mann D, Harris J M, Chartier-Harlin M-C, Cummings A, Coates J, Lemmon H, St-Clair D, Iwatsubo T, Lendon C: The -48 CT polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer’s disease and an increased Aβ load in brain. J Medical Genetics 38:353-355, 2001

Iwata H, Tomita T, Maruyama K, Iwatsubo T: Subcellular compartment and molecular subdomain of β-amyloid precursor protein relevant to the Aβ42-promoting effects of Alzheimer mutant presenilin 2. J Biol Chem 276: 21678-21685, 2001

Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptide 1-40 and 1-42 most effectively among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276: 21895-21901, 2001

Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T: Amyloid angiopathy and variability in Amyloid β deposition is determined by mutation position in presenilin-1 linked Alzheimer’s disease. Am J Pathol 158: 2165-2175, 2001

Verkkoniemi A, Kalimo H, Paetau A, Somer M, Iwatsubo T, Hardy J, Haltia M: Variant Alzheimer’s disease with spastic paraparesis: Neuropathological phenotype. J Neuropathol Exp Neurol 60: 483-492, 2001

Mann DMA, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T: Amyloid β protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neurosci Lett 304:161-164, 2001

Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49:501-511, 2001

Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi T: Co-localization of α-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 101:285-293, 2001

Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y: Molecular cloning and expression of the novel splice variants of K+ channel-interacting protein 2 (KChIP2). Biochem Biophys Res Comm 282:96-102, 2001

Lambert J-C, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon CL, Chartier-Harlin M-C: Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer’s disease. Lancet 357:608-609, 2001

Lee J-A, Long, Z, Nimura N, Iwatsubo T, Imai K, Homma H: Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands. Arch Biochem Biophys 385:242-249, 2001

Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS letters 489: 46-50, 2001