Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M: Concise and short synthesis of functionalized 5,6-dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates. Heterocycles 70:101-106, 2006

Zhu X, Babar A, Siedlak LS, Yang Q, Ito G, Iwatsubo T, Smith MA, Perry G, Chen SG. LRRK2 in Parkinson’s disease and dementia with Lewy bodies. Molecular Neurodegeneration 1:17, 2006

Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R: AMPA-R removal underlies Aβ-induced synaptic depression. Neuron 52:831-843, 2006

Sato C, Morohashi Y, Tomita T, Iwatsubo T: Structure of the catalytic pore of γ-secretase inferred by the accessibility of substituted cysteines. J Neurosci 26: 12081-12088, 2006

Ozaki , Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A: The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis. Biochem Biophys Res Comm 351:57-63, 2006

Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS, Kim J, Paik SR, Chung KC: Dyrk1A phosphorylates α-synuclein and enhances intracellular inclusion formation. J Biol Chem 281: 33250-33257, 2006

Arawaka S, Wada M, Goto S, Karube H, Sakamoto M, Ren C-H, Koyama S, Nagasawa H, Kimura H, Kawanami T, Kurita K, Tajima K, Daimon M, Baba M, Kido T, Saino S, Goto K, Asao H, Kitanaka C, Takashita E, Hongo S, Nakamura T, Kayama T, Suzuki Y, Kobayashi K, Katagiri T, Kurokawa K, Kurimura M, Toyoshima I, Tsuchiya K, Iwatsubo T, Muramatsu M, Matsumine H, Kato T: The role of G protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson’s disease. J Neurosci 26:9227-9238, 2006

Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H: Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors. Bioorganic & Medicinal Chemistry Letters 16:4184-4189, 2006

Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H: Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies. J Neurol Sci 246:95-101, 2006

Tomita T, Tanaka S, Morohashi Y, Iwatsubo T: Presenilin-dependent intramembrane cleavage of ephrin-B1. Molecular Neurodegeneration 1:2 (doi:10.1186/1750-1326-1-2), 2006

Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zola P, Arima K, Iseki E, Murayama S, Kretzchmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Khan N, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Mann DMA: Comparison of extent of tau pathology in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer’s disease. Neuropathol Appl Neurobiol 32:374-387, 2006

Bensemain F, Chapuis J, Tian J, Shi J, Thaker U, Lendon C, Iwatsubo T, Amouyel P, Mann D, Lambert J-C: Association study of the ubiquilin gene with Alzheimer’s disease. Neurobiol Dis 22:691-693, 2006

Tamaki C, Ohtsuki S, Iwatsubo T, Hashimoto T, Yamada K, Yabuki C, Terasaki T: Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid β-peptide by the liver. Pharmaceut Res 23: 1407- 1416, 2006

Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quelever G, Iwatsubo T, Kraus J-L: Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays. J Med Chem 49:4275-4285, 2006

Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T: Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorganic & Medicinal Chemistry Letters 16:3813-3816, 2006

Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T: Carboxyl-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT. J Biol Chem 281: 14670-14676, 2006

Masuda M, Suzuki N, Taniguchi S, Oikawa T, Nonaka T, Iwatsubo T, Hisanaga S-i, Goedert M, Hasegawa M: Small molecule inhibitors of α-synuclein filament assembly. Biochemistry 45:6085-6094, 2006

Tian J, Shi J, Smallman R, Iwatsubo T, Mann DMA Relationships in Alzheimer’s disease between the extent of Aβ deposition in cerebral blood vessel walls, as cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle cells and collagen. Neuropathol Appl Neurobiol 32: 332-340, 2006

de Silva R, Lashley T, Strand C, Shiarli A-M, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, MacKenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DMA: An immunohisto- chemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol 111: 329-340, 2006

Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C: Three-dimensional structure of the γ-secretase complex. Biochem Biophys Res Comm 343: 525-534, 2006

Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DMA: Genetic associations between cathepsin D exon 2 CRT polymorphism and Alzheimer’s disease, and pathological correlations with genotype. J Neurol Neurosurg Psychiatry 77: 515-517, 2006

Shi J, Tian J, Pritchard A, Lendon C, Lambert J-C, Iwatsubo T, Mann DMA: A 3’-UTR polymorphism in the oxidized LDL receptor 1 gene increases Aβ40 load as cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 111:15-20, 2006

Ito G, Ariga H, Nakagawa Y, Iwatsubo T: Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1. Biochem Biophys Res Comm 339:667-672, 2006

Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T: Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic C. elegans. J Biol Chem 281:334-340, 2006

McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM-Y, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, for the Consortium on DLB: Dementia with Lewy Bodies: Diagnosis and Management: Third Report of the DLB Consortium. Neurology 65:1863-1872, 2005

Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel D, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K: Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J 19:2069-2071, 2005

Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T: Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin 1. J Biol Chem 280:41967-41975, 2005

Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E: Neurological and neurodegenerative alterations in a transgenic mouse model expressing α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci 25:10689-10699, 2005

Lambert JC, Mann D, Richard F, Tian J, Shi J, Thaker U, Merrot S, Harris J, Frigard B, Iwatsubo T, Lendon C, Amouyel P: Is there a relation between APOE expression and brain amyloid load in Alzheimer’s disease? J Neurol Neurosurg Psychiatry 76:928-933, 2005

Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA: α-Synuclein phosphorylation enhances Lewy body-like inclusion formation in SH-SY5Y cells. J Neurosci 25:5544-5552, 2005

Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon C: Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimer’s disease. Neurosci Lett 382:221-226, 2005

Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno Y, Hattori N: Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells. Biochem Biophys Res Commun 332:233-240, 2005

Iseki E, Marui W, Yamamoto R, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H: The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neurosci Lett 380:161-165, 2005

Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T: Association of active γ-secretase complex with lipid rafts. J Lipid Res 46:904-912, 2005

Niimura M, Isoo N, Takasugi N, Tsuruoka M, Tei-Ui K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T: Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter- and intramolecular interactions. J Biol Chem 280: 12967-12975, 2005

Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T: CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280: 8596-8605, 2005

Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M: Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins. J Biol Chem 280: 7614-7623, 2005

Nonaka T, Iwatsubo T, Hasegawa M: Ubiquitination of α-synuclein. Biochemistry 44:361-368, 2005