Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG, Walls KC, Shacka JJ, Roth KA, Zhan J: Lysosomal enzyme cathepsin D protects against α-synuclein aggregation and toxicity. Molecular Brain 1:17, 2008

Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T: The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid β peptides in an in vitro model of the blood-brain barrier cells. J Biol Chem 283: 34554-34562, 2008

Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe, M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S: Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 67:945-953, 2008

Kuwahara T, Koyama A, Koyama S, Yoshina S, Ren C-H, Kato T, Mitani S, Iwatsubo T: A large-scale RNA interference screen identifies endocytic pathway genes as modifiers of α-synuclein toxicity in transgenic Caenorhabditis elegans. Human Molecular Genetics 17:2997-3009, 2008

Beach TG, White CL, Hamilton RL, Duda JE, Iwatsubo T, Dickson DW, Leverenz JB, Roncaroli F, Buttini M, Hladik CL, Sue LI, Noorigian JV, Adler CH: Evaluation of α-synuclein immunohistochemical methods used by invited experts. Acta Neuropathol 116:277-288, 2008

Lo Bianco C, James Shorter C, Regulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P: Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson’s disease. J Clin Invest 118:3087-3097, 2008

Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL: Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors. J Enzyme Inhib Med Chem 7:1, 2008

Cheung K-H, Shineman D, Muller M, Cardenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM-Y, Foskett K: Mechanism of Ca2+ disruption in Alzheimer’s disease by presenilin regulation of InsP3 receptor channel gating. Neuron 58:871-883, 2008

Sato C, Takagi S, Tomita T, Iwatsubo T: The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the γ-secretase. J Neurosci 28: 6264-6271, 2008

Ichibangase T, Saimaru H, Takamura N, Kuwahara T, Koyama A, Iwatsubo T, Imai K: Proteomics of Caenorhabditis elegans overexpressing human α-synuclein analyzed by FD-LC-MS/MS method: actin and several ribosomal proteins were identified as negative markers at early Parkinson’s disease stages. Biomedical Chromatography 22:232-234, 2008

Obi, K Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H: Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 210:409-420, 2008

Yoshihara T, Takiguchi S, Kyuno A, Tanaka K, Kuba S, Hashiguchi S, Ito Y, Hashimoto T, Iwatsubo T, Tsuyama S, Nakashima T, Sugimura K: Immunoreactivity of phage library-derived human single-chain antibodies to amyloid β conformers in vitro. J Biochem 143:475-486, 2008

Akanuma SI, Ohtsuki S, Doi Y, Tachikawa M, Ito S, Hori S, Asashima T, Hashimoto T, Yamada K, Ueda K, Iwatsubo T, Terasaki T: ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier. Neurochem Int 52:956-961, 2008

Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG: Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson’s disease, but not tau-containing deposits in tauopathies. Neurodegener Dis 5: 222-224, 2008

Ikeuchi T, Kakita A, Shiga A, Kasuga K, Kaneko H, Tan C-F, Idezuka J, Wakabayashi K, Onodera O, Iwatsubo T, Nishizawa M, Takahashi H, Ishikawa A: Homozygous and heterozygous patients for SNCA duplication in family with parkinsonism and dementia. Arch Neurol 65:514-519, 2008

Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S-i, Kobayashi K, Iwatsubo T, Yoshimoto M: Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice. Neurobiol Aging 29:574-585, 2008

Kumano K, Masuda S, Sata M, Saito T, Lee S-Y, Sakata-Yanagimoto M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S. Both Notch1 and Notch2 contribute to the regulation of melanocytehomeostasis. Pigment Cell & Melanoma Research 21:70-78, 2008

Takatori S. Ito G, Iwatsubo T: Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. Neurosci Lett 430:13-17, 2008

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T: Enhanced accumulation of phosphorylated α-synuclein and elevated Aβ42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer disease. J Neurosci 27:13092-13, 2007

Sasakawa H, Sakata E, Yamaguchi Y, Masuda M, Mori T, Kurimoto E, Iguchi R, Hisanaga S-i, Iwatsubo T, Hasegawa M, Kato K: 920 MHz ultra-high field NMR studies of antibody binding and site-specific phosphorylation of α-synuclein. Biochem Biophys Res Comm 363:795-799, 2007

Ishii A, Nonaka T, Taniguchi S, Saito T, Arai, T, Mann D, Iwatsubo T, Hisanaga S-i, Goedert M, Hasegawa M: Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human α-synuclein: Implication for α-synucleinopathies. FEBS letters 581:4711-4717, 2007

Kato M, Kinoshita H, Enokita M, Hori Y, Hashimoto T, Iwatsubo T, Toyo’oka T: Analytical method for β-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of β-amyloid protein aggregation. Anal Chem 79:4887-4891, 2007

Fuwa H, Takahashi Y, Konno Y, Watanabe N, Miyashita H, Sasaki M, Natsugari H, Kan T, Fukuyama T, Tomita T, Iwatsubo T: Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic γ-secretase inhibitors. ACS Chemical Biology 2:408-418, 2007

Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T: Convenient synthesis of photoaffinity probes and evaluation of their labeling abilities. Org Lett 9:2055-2058, 2007

Yamamoto R, Iseki E, Murayama N, Minegishi M, Marui W, Togo T, Katsuse O, Kosaka K, Kato M, Iwatsubo T, Arai H: Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies. Neurosci Lett 415:219-224, 2007

Wakamatsu M, Ishii A, Ukai Y, Sakagami J, Iwata S, Ono M, Matsumoto K, Nakamura A, Tada N, Kobayashi K, Iwatsubo T, Yoshimoto M: Accumulation of phosphorylated α-synuclein in dopaminergic neurons of transgenic mice that express human α-synuclein. J Neurosci Res 85:1819-1825, 2007

Haleem K, Lippa CF, Wong M, Abdelhak T, Smith TW, Kowa H, Iwatsubo T: Space-occupying plaques in PS-1 C410Y Alzheimer’s disease contain synaptic- terminal specific proteins. American Journal of Alzheimer’s Disease 22:137-144, 2007

Fumimura Y, Ikemura M, Saito Y, Sengoku R, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Mizusawa H, Murayama S: Analysis of adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 66: 354-362, 2007

Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T: Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: common effects of Pen-2 amino-terminal elongation and fenofibrate. J Biol Chem 282:12388-12396, 2007

Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz JB, Masliah E, McKeith IG, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK, for the DLB/PDD working Group: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and Biomarkers. Neurology 68:812-819, 2007

Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T: The Tottori (D7N) and English (H6R) familial Alzheimer’s disease mutations accelerate Aβ fibril formation without increasing protofibril formation. J Biol Chem 282: 4916-4923, 2007

Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T: GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease. Biochemistry 46:1380-1388, 2007