Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zheng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T: Activity-dependent proteolytic cleavage of neuroligin-1. Neuron 76:410-422, 2012

Takeo K, Watanabe N, Tomita T, Iwatsubo T: Contribution of γ-secretase cofactors to the formation of catalytic pore of presenilin 1. J Biol Chem 287:25834-25843, 2012

Goto M, Abe O, Miyati T, Kabasawa H, Takao H, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Aoki S, Ino K, Iida K, Yano K, Ohtomo K, Japanese Alzheimer’s Disease Neuroimaging Initiative: Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method. Korean Journal of Radiology 13:391-402, 2012

Goto M, Abe O, Kabasawa H, Takao H, Miyati T, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Inano S, Mori H, Kunimatsu A, Aoki S, Ino K, Yano K, Ohtomo K, Japanese Alzheimer’s Disease Neuroimaging Initiative: Effects of Image Distortion Correction on Voxel-based Morphometry. Magneteic Resonance in Medical Sciences 11:27-34, 2012

Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider B, Lee M: Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci 32:3306-3320, 2012

Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T: Phosphorylation at Ser129 reduces α-synuclein neurotoxicity by lowering its membrane-binding property in Caenorhabditis elegans. J Biol Chem 287:7098-7109, 2012

Hayashi I, Takatori S, Urano Y, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T: Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin. Oncogene 31:787-798, 2012

Ito G, Iwatsubo T: Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form. Biochem J 441:987-994, 2012

Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S: Comparison of preselinin1 and presenilin 2 γ-secretase activities using a yeast reconstitution system. J Biol Chem 286:44569-44575, 2011

Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H: Ku70 alleviates neurodegeneration in Drosophila models of Huntington’s disease. PLoS One 6:e27408, 2011

Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T: Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J 30:4815-4824, 2011

Miyashita H, Maruyama Y, Isshiki H, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T: Three-dimensional structure of the signal peptide peptidase. J Biol Chem 286: 26188-26197, 2011

Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S-i, Kamiie J, Hashimoto T, Hosoya K-i, Iwatsubo T, Terasaki T: Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. J Neurochem 118:407-415, 2011

Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH: Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:280-292, 2011

Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T: BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. J Neurosci 31: 6850-6857, 2011