Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T: Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase. J Neurosci 30: 15943-15950, 2010

Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K: Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer’s disease. J Neurosci Res 88:3588-3597, 2010

Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M: Seeded aggregation and toxicity of α-synuclein and tau: cellular models of neurodegenerative diseases. J Biol Chem 285:34885-34898, 2010

Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H: Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator- activated receptor agonist library. Bioorg Med Chem Lett 20:5282-5285, 2010

Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M: A non-competitive BACE1 inhibitor TAK-070 ameliorates Aβ pathology and behavioral deficits in a mouse model of Alzheimer’s disease. J Neurosci 30:11157-11166, 2010

Watanabe N, Takagi S, Tomita T, Iwatsubo T: Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate binding site of γ-secretase. J Biol Chem 285:19738-19746, 2010

Cheung KH, Mei L, Mak DOD, Hayashi I, Iwatsubo T, Kang DE, Foskett JK: Gain of function Alzheimer’s disease presenilin regulation of InsP3 receptor modal gating in patient cells and AD mouse neurons. Science Signaling 3:ra22, 2010

Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S: Dual antitumor mechanisms of Notch signaling inhibitor in a T cell acute lymphoblastic leukemia xenograft model. Cancer Sci 100:2444-2450, 2009

Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T: Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker. Bioorg Med Chem Lett 19:6869-6871, 2009

Kamikawaji S, Ito G, Iwatsubo T: Identification of the autophosphorylation sites of LRRK2. Biochemistry 48:10963-10975, 2009

Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrieze F, Dartigues JF, Tzourio C, Buee L, Pasquier F, Berr C, Mann D, Lendon C, Alperovitch A, Kamboh MI, Amouyel P, Lambert JC: Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease. Mol Psychiatr 14:1004-1016, 2009

Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T: Single chain variable fragment against Nicastrin inhibits the γ-secretase activity. J Biol Chem 284:27838-27847, 2009

Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T: Aβ immunotherapy: intracerebral sequestration of Aβ by an anti-Aβ monoclonal antibody 266 with high affinity to soluble Aβ. J Neurosci 29: 11393-11398, 2009

Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B: LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 29:9210-9218, 2009

Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H: Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol Pharm Bull 32:999-1003, 2009

Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T: Inhibition of γ-secretase activity by helical β-peptide foldamers. J Am Chem Soc 131:7353-7359, 2009

Azeredo da Silveira S, Schneider BL, Cifuentes-Diaz C, Sage D, Abbas-Terki T, Iwatsubo T, Unser M, Aebischer P: Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson’s disease. Human Molecular Genetics 18: 872-887, 2009

Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G: s-Palmitoylation of γ-secretase subunits nicastrin and Aph-1. J Biol Chem 284:1373-1384, 2009