Villemagne V L, Kim S Y, Rowe C C, Iwatsubo T: Imago Mundi, Imago AD, Imago ADNI. Alzheimers Res Ther 6:62, 2014

Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev I K, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T, Iwatsubo T: Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator. Proc Natl Acad Sci U S A 111:10544-10549, 2014

Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T: New photocleavable linker: alpha-thioacetophenone-type linker. Bioorg Med Chem Lett 24:2831-2833, 2014

Ito G, Fujimoto T, Kamikawaji S, Kuwahara T, Iwatsubo T: Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955. PLoS One 9:e97988, 2014

Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T: Decreased CALM expression reduces Abeta42 to total Abeta ratio through clathrin-mediated endocytosis of gamma-secretase. Nat Commun 5:3386, 2014

Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T: CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci 34:1370-1379, 2014

Doody R S, Thomas R G, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen P S, Siemers E, Liu-Seifert H, Mohs R: Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease. N Engl J Med 370:311-321, 2014

Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T: Binding of longer Abeta to transmembrane domain 1 of presenilin 1 impacts on Abeta42 generation. Mol Neurodegener 9:7, 2014

Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M: Attenuation of the aggregation and neurotoxicity of amyloid-beta peptides by catalytic photooxygenation. Angew Chem Int Ed Engl 53:1382-1385, 2014

Li Y, Lu S H, Tsai C J, Bohm C, Qamar S, Dodd R B, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman B T, Tomita T, Iwatsubo T, Johnson C M, Farrer L A, Schmitt-Ulms G, Fraser P E, St George-Hyslop P H: Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure 22:125-135, 2014

Imabayashi E, Matsuda H, Tabira T, Arima K, Araki N, Ishii K, Yamashita F, Iwatsubo T: Comparison between brain CT and MRI for voxel-based morphometry of Alzheimer’s disease. Brain Behav 3:487-493, 2013

Kamikawaji S, Ito G, Sano T, Iwatsubo T: Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation. Biochemistry 52:6052-6062, 2013

Doody R S, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas R G, Aisen P S, Siemers E, Sethuraman G, Mohs R: A phase 3 trial of semagacestat for treatment of Alzheimer’s disease. N Engl J Med 369:341-350, 2013

Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T: Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana. BMC Biochem 14:16, 2013

Ihara R, Matsukawa K, Nagata Y, Kunugi H, Tsuji S, Chihara T, Kuranaga E, Miura M, Wakabayashi T, Hashimoto T, Iwatsubo T: RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. Hum Mol Genet 22:4474-4484, 2013

Maikusa N, Yamashita F, Tanaka K, Abe O, Kawaguchi A, Kabasawa H, Chiba S, Kasahara A, Kobayashi N, Yuasa T, Sato N, Matsuda H, Iwatsubo T: Improved volumetric measurement of brain structure with a distortion correction procedure using an ADNI phantom. Med Phys 40:062303, 2013

Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T: FTY720/fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons. PLoS One 8:e64050, 2013

Goto M, Abe O, Aoki S, Hayashi N, Miyati T, Takao H, Iwatsubo T, Yamashita F, Matsuda H, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K: Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra provides reduced effect of scanner for cortex volumetry with atlas-based method in healthy subjects. Neuroradiology 55:869-875, 2013

Tomita T, Iwatsubo T: Structural biology of presenilins and signal peptide peptidases. J Biol Chem 288:14673-14680, 2013

Takahashi R, Ishii K, Senda M, Ito K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T: Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Ann Nucl Med 27:452-459, 2013

Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T: Effect of helical conformation and side chain structure on gamma-secretase inhibition by beta-peptide foldamers: insight into substrate recognition. J Med Chem 56:1443-1454, 2013

Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T: Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1. Biochemistry 52:61-69, 2013