Matsukawa K, Hashimoto T, Matsumoto T, Ihara R, Chihara T, Miura M, Wakabayashi T, Iwatsubo T: ALS-linked mutations in profilin 1 exacerbate degeneration in the retina of Drosophila melanogaster through increasing the cytoplasmic localization of TDP-43. J Biol Chem 291:23464-23476, 2016

Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T: BIN1 regulates BACE1 intracellular trafficking and amyloid-β production. Hum Mol Genet 25:2948-2958, 2016

Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T: Partial loss of CALM function reduces A42 production and amyloid deposition in vivo. Hum Mol Genet pii: ddw239, 2016

Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M: Phantom criteria for qualification of brain FDG and amyloid PET across different cameras EJNMMI Physics 3:23, 2016

Kuwahara T, Inoue K, D’Agati VD, Fujimoto T, Eguchi T, Saha S, Wolozin B, Iwatsubo T, Abeliovich A: LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Sci Rep 6:29945, 2016

Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T: A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Sci Rep 6:23969, 2016

Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T: Conformational changes in transmembrane domain 4 of presenilin 1 are associated with altered Abeta42 production. J Neurosci 36:1362-1372, 2016

Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DMA, Iwatsubo T, Hasegawa M: Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol 131:267-280, 2016

Doody RS, Raman, R Sperling RA, Siemers E, Sethuraman G, Mohs R, Farlow MR, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS; Alzheimer’s Disease Cooperative Study: Peripheral and central effects of gamma-secretase inhibition by semagacestat in Alzheimer’s disease. Alzheimer’s Research & Therapy 7:36, 2015

Yamamoto K, Tanei Z I, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno L E, Fukayama M, Bito H, Cirrito J R, Holtzman D M, Deisseroth K, Iwatsubo T: Chronic Optogenetic Activation Augments Abeta Pathology in a Mouse Model of Alzheimer Disease. Cell Rep 11:859-865, 2015

Hori Y, Hashimoto T, Nomoto H, Hyman B T, Iwatsubo T: Role of apolipoprotein E in beta-amyloidogenesis: isoform-specific effects on protofibril to fibril conversion of Abeta in vitro and brain Abeta deposition in vivo. J Biol Chem, 2015

Kukharsky M S, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman V L, Shelkovnikova T A: Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis. Mol Neurodegener 10:20, 2015

Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T: Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of gamma-secretase. J Neurosci 35:2646-2656, 2015

Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T: Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity. Biochem Biophys Res Commun 457:194-199, 2015

Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K: Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer’s disease: a preliminary study. Radiol Phys Technol 8:64-72, 2015

Tagawa K, Homma H, Saito A, Fujita K, Chen X, Imoto S, Oka T, Ito H, Motoki K, Yoshida C, Hatsuta H, Murayama S, Iwatsubo T, Miyano S, Okazawa H: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer’s disease brain. Hum Mol Genet 24:540-558, 2015