Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T: Clinical and cognitive characteristics of preclinical Alzheimer’s disease in the Japanese ADNI cohort. Alzheimers Dementia: Translational Research& Clinical Interventions 4:645-651, 2018

Iwata A, Iwatsubo T, Ihara R, Suzuki K, Matsuyama Y, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H: Effects of gender, educational background, and renal function on cognitive and functional decline in Japanese patients with mild cognitive impairment. Alzheimers Dementia: Translational Research & Clinical Interventions 4:765-774, 2018

Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci USA 115:E9115-E9124, 2018

Mann DMA, Davidson YS, Robinson AC, Allen N, Hashimoto T, Richardson A, Jones M, Snowden JS, Pendleton N, Potier MC, Laquerriere A, Prasher V, Iwatsubo T, Strydom A: Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease. Acta Neuropathol 136:569-587, 2018

Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC: Japanese and North American Alzheimer’s Disease Neuroimaging Initiative studies: harmonization for international trials. Alzheimers Dementia 14:1077-1087, 2018

Matsumoto T, Matsukawa K, Watanabe N, Kishino Y, Kunugi H, Ihara R, Wakabayashi T, Hashimoto T, Iwatsubo T: Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Hum Mol Genet 27: 1353-1365, 2018

Yamada K, Iwatsubo T: Activity-dependent pathway determines extracellular alpha-synuclein levels. Molecular Neurodegeneration 13:9, 2018

Fujimoto T, Kuwahara T, Eguchi T, Sakurai M, Komori T, Iwatsubo T: Parkinson’s disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology. Biochem Biophys Res Commun 495:1708-1715, 2018

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T: Loss of kallikrein-related peptidase 7 derived from astrocytes exacerbates amyloid pathology in Alzheimer disease model mouse. EMBO Mol Med pii: e8184, 2018

Mano T, Tsuchida T, Ohtomo R, Nagata K, Takahashi-Fujigasaki J, Murayama S, Saido TC, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Ikeuchi T, Iwatsubo T, Tsuji S, Iwata A: Epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease. Proc Natl Acad Sci USA 114:E9645-E9654, 2017

Yamamoto T, Furihata K, Hisaka A, Moritoyo T, Furihata S, Ogoe K, Kusayama S, Motohashi K, Mori A, Iwatsubo T, Suzuki H: Notable drug-drug interaction between etizolam and itraconazole in poor metabolizers of cytochrome P450 2C19. J Clin Pharmacol 57:1491-1499, 2017

Fujishima M, Kawaguchi A, Maikusa N, Kuwano R, Iwatsubo T, Matsuda H, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI): Sample size estimation for Alzheimer’s disease trials from Japanese ADNI serial MRI. J Alzheimers Dis 56:75-88, 2017