Yoshida K, Seo M, Yan L, Sahker E, Cipriani A, Leucht S, Iwatsubo T, Efthimiou O, Furukawa TA: Personalized prediction of Alzheimer’s disease and its treatment effects by donepezil: an individual participant data meta-analysis of eight randomized controlled trials. J Alz Dis 89:1143-1157, 2022

de Erausquin GA, Snyder HM, Brugha TS, Seshadri S, Carrillo M, Sagar R, Huang Y, Newton C, Tartaglia C, Teunissen C, Håkanson K, Akinyemi R, Prasad K, D’Avossa G, Gonzalez-Aleman G, Hosseini A, Vavougios GD, Sachdev P, Bankart J, Ole Mors NP, Lipton R, Katz M, Fox PT, Katshu MZ, Iyengar MS, Weinstein G, Sohrabi HR, Jenkins R, Stein DJ, Hugon J, Mavreas V, Blangero J, Cruchaga C, Krishna M, Wadoo O, Becerra R, Zwir I, Longstreth WT, Kroenenberg G, Edison P, Mukaetova-Ladinska E, Staufenberg E, Figueredo-Aguiar M, Yécora A, Vaca F, Zamponi HP, Lo Re V, Majid A, Sundarakumar J, Gonzalez HM, Geerlings MI, Skoog I, Salmoiraighi A, Boneschi FM, Patel VN, Santos JM, Arroyo GR, Moreno AC, Felix P, Gallo C, Arai H, Yamada M, Iwatsubo T, Sharma M, Chakraborty N, Ferreccio C, Akena D, Brayne C, Maestre G, Blangero SW, Brusco LI, Siddarth P, Hughes TM, Zuñiga AR, Kambeitz J, Laza AR, Allen N, Panos S, Merrill D, Ibáñez A, Tsuang D,Valishvili N, Shrestha S, Wang S, Padma V, Anstey KJ, Ravindrdanath V, Blennow K, Mullins P, Łojek E, Pria A, Mosley TH, Gowland PG, Girard TD, Bowtell R, Vahidy FS: Chronic neuropsychiatric sequelae of SARS-CoV2: Protocol 1 and methods from the Alzheimer’s Association Global Consortium. submitted to Alzheimers Dementia: Translational Research & Clinical Interventions 8:e12348, 2022

Sato K, Niimi Y, Iwatsubo T, Ishii S: Change in long-term care service usage in Japan following the COVID-19 pandemic: a survey using a nationwide statistical summary in 2018–2021. Geriatr Gerontol Int 22:803-809, 2022

Kasuga K, Kikuchi M, Tsukie T, Suzuki K, Ihara R, Iwata A, Hara N, Miyashita A, Kuwano R, Iwatsubo T, Ikeuchi T: Characterization of ATN profile classified using two different N markers in CSF. BMJ Neurol Open 4:e000321, 2022

Poulakis K, Pereira JB, Muehlboeck J-S, Wahlund L-O, Smedby Ö, Volpe G, Masters CL, Ames D, Niimi Y, Iwatsubo T, Ferreira D, Westman E: Stage vs. Subtype hypothesis in Alzheimer’s disease: a multi-cohort and longitudinal Bayesian clustering study. Nat Commun 13:4566, 2022

Kishino Y, Matsukawa K, Matsumoto T, Wakabayashi T, Nonaka T, Kametani F, Hasegawa M, Hashimoto T, Iwatsubo T: Casein kinase 1d/e phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration. J Biol Chem 298: 102191, 2022

Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T: Automated evaluation of conventional clock-drawing test using deep neural network: potential as a mass screening tool to detect individuals with cognitive decline. Front Neurol 13:896403, 2022

Sato K, Niimi Y, Mano T, Iwata A, Iwatsubo T: Time to onset of drug-induced parkinsonism: Analysis using a large Japanese adverse event self-reporting database. Biosci Trends 16:151-157, 2022

Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Jiayi L, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T, Ikeuchi T, Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M: Actin-1 binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Sci Adv 8:eabm5029, 2022

Haeberlein SB, Aisen PS, Barkhof F, Chalkias S, Chen T, Cohen S, Dent G, Hansson O, Harrison K, von Hehn C, Iwatsubo T, Mallinckrodt C, Mummery CJ, Muralidharan KK, Nestorov I, Nisenbaum L, Rajagovindan R, Skordos L, Tian Y, van Dyck CH, Vellas B, Wu S, Zhu Y, Sandrock A: Two randomized phase 3 studies to evaluate aducanumab in early Alzheimer disease. J Prev Alzheimers Dis 9:197-210, 2022

Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N: Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease. iScience 25:103869, 2022

Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, Yasui M, Iwatsubo T: Glymphatic system clears extracellular tau and protect from tau aggregation and neurodegeneration. J Exp Med 219:e20211275, 2022

Levine SZ, Goldberg Y, Yoshida K, Efthimiou O, Samara M, Cipriani A, Iwatsubo T, Leucht S, Furawaka TA: Early- and subsequent- response of cognitive functioning in Alzheimer’s disease: Individual-participant data from five pivotal randomized clinical trials of donepezil. J Psychiatr Res 148:159-164, 2022

Rotstein A, Levine SZ, Samara M, Yoshida K, Goldberg Y, Cipriani A, Iwatsubo T, Leucht S, Furawaka TA: Cognitive impairment networks in Alzheimer’s disease: Analysis of three double-blind randomized, placebo-controlled, clinical trials of donepezil. Eur Neuropsychopharmacol 57:50-58, 2022

Kazawa K, Akishita M, Ikeda M, Iwatsubo T, Ishii S: Experts’ perception of support for people with dementia and their families during the COVID-19 pandemic. Geriatr Gerontol Int 22:26-31, 2022

An H, Litscher G, Watanabe N, Wei W, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova T: ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity. Neurobiol Dis 162:105585, 2022

Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, Wei R, Huo A, Saito T, Ando K, Murayama S, Araki W, Kametani F, Hasegawa M, Iwatsubo T, Tomomura M, Fukuda M, Hisanaga S-I: Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of beta-secretase BACE1. J Biochem 170:729–738, 2021

Koh HS, Lee SJ, Lee HJ, Min J-W, Iwatsubo T, Teunissen CE, Cho H-J, Ryu J-H: Targeting microRNA-485-3p blocks Alzheimer’s disease progression. Int J Mol Sci 22:13136, 2021

Sato K, Mano T, Niimi Y, Iwata A, Toda T, Iwatsubo T: The impact of COVID-19 pandemic on the provision of ambulatory care for patients with chronic neurological diseases in Japan: evaluation of an administrative claims database. BioScience Trends 15:219-230, 2021

Samara MT, Levine SZ, Yoshida K, Goldberg Y, Clipriani A, Efthimiou O, Iwatsubo T, Leucht S, Furukawa TA: Linking the clinical dementia rating scale-sum of boxes, the clinician’s interview-based impression plus caregiver input and the clinical global impression scale: Evidence based on individual participant data from five randomized clinical trials of donepezil. J Alz Dis 82:1075-1084, 2021

Ochiai T, Sano T, Kubota N, Kadowaki T, Wakabayashi T, Iwatsubo T: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects of their deficiency on amyloid pathology in Alzheimer’s disease. Neurobiol Dis 159:105510, 2021

Sato K, Mano T, Niimi Y, Toda T, Iwata A, Iwatsubo T: Facial nerve palsy following the administration of mRNA COVID-19 vaccines. Int J Infect Dis 111:310-312, 2021

Sato K, Mano T, Ihara R, Suzuki K, Toda T, Iwatsubo T, Iwata A: Cohort-specific optimization of models predicting preclinical Alzheimer’s disease, to enhance screening performance in the middle of preclinical Alzheimer’s disease clinical studies. J Prev Alzheimers Dis 8:503-512, 2021

Senda M, Ishii K, Ito K, Ikeuchi T, Matsuda H, Iwatsubo T, Iwata A, Ihara R, Suzuki K, Kasuga K, Ikari Y, Niimi Y, Arai H, Tamaoka A, Arahata Y, Itoh Y, Tachibana H, Ichimiya Y, Washizuka S, Odawara T, Ishii K, Ono K, Yokota T, Nakanishi A, Matsubara E, Mori H, Shimada H: A Japanese multicenter study on PET and other biomarkers for subjects with potential preclinical and prodromal Alzheimer’s disease. J Prev Alzheimers Dis 8:495-502, 2021

Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T, Iwatsubo T: Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease. J Prev Alzheimers Dis 4:483-494, 2021

Mano T, Sato K, Ikeuchi T, Toda T, Iwatsubo T, Iwata A: Peripheral blood BRCA1 methylation positively correlates with major Alzheimer’s disease risk factors. J Prev Alzheimers Dis 8:477-482, 2021

Sato K, Niimi Y, Ihara R, Suzuki K, Toda T, Iwata A, Iwatsubo T: Efficacy and cost-effectiveness of multiple promotion methods to recruit participants to online screening registry for the facilitation of Alzheimer’s disease prevention trials. J Med Internet Res 23:e26284, 2021

Levine SZ, Yoshida K, Goldberg Y, Samara M, Cipriani A, Efthimiou O, Iwatsubo T, Leucht S, Furukawa TA: Linking the Mini-Mental State Examination, the Alzheimer’s Disease Assessment Scale-Cognitive Subscale and the Severe Impairment Battery: Evidence from five randomized clinical trials. Evid Based Ment Health 24:56-61, 2021

Levine SZ, Goldberg Y, Yoshida K, Samara M, Cipriani A, Iwatsubo T, Leucht S, Furuwaka TA: Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: latent class analysis of individual-participant data from Five pivotal randomized clinical trials of donepezil. European Psychiatr 64: e16, 2021

Sato K, Ihara R, Suzuki K, Niimi Y, Toda T, Jimenez-Maggiora G, Langford O, Donohue MC, Raman R, Aisen PS, Sperling RA, Iwata A, Iwatsubo T: Predicting amyloid risk by machine learning algorithms based on the A4 screen data: application to the Japanese Trial-Ready Cohort study. Alzheimers Dementia: Translational Research & Clinical Interventions 7:e12135, 2021

Matsukawa K, Kukharsky, Park S-K, Park S, Iwatsubo T, Hashimoto T, Liebman S, Shelkovnikova T: Long non-coding RNA NEAT1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy. RNA Biol 1-9, 2021